研究業績

2021

  1. Hasan N, Nagata N, Morishige J, Islam MT, Jing Z, Harada K, Mieda M, Ono M, Fujiwara H, Daikoku T, Fujiwara T, Maida Y, Ota T, Shimba S, Kaneko S, Fujimura A, Ando H. Brown adipocyte-specific knockout of Bmal1 causes mild but significant impairment of thermogenesis in mice. Mol Metab, in press

  2. Nagata N, Kawasumi M, Fujimura A, Ando H. Edoxaban dosing time affects blood coagulation inhibition in rats. TH Open, in press

  3. Maeda A, Irie K, Hashimoto N, Fukushima S, Ando H, Okada A, Ebi H, Kajita M, Iwata H, Sawaki M. Serum concentration of the CKD4/6 inhibitor abemaciclib, but not of creatinine, strongly predicts hematological adverse events in patients with breast cancer: a preliminary report. Invest New Drugs. 2021 Feb;39(1):272-277. doi: 10.1007/s10637-020-00994-3. Epub 2020 Aug 27.PMID: 32856274

  4. Ali H, Yamashita R, Morishige JI, Morito K, Kakiuchi N, Hayashi J, Aihara M, Kawakami R, Tsuchiya K, Tanaka T. Mass Spectrometric Analysis of Sphingomyelin with N-α-Hydroxy Fatty Acyl Residue in Mouse Tissues Lipids. 2020 Sep 30. doi: 10.1002/lipd.12285. Online ahead of print.

2020

  1. Abe T, Okuyama K, Kamada M, Yano S, Toyama Y, Isomura M, Nabika T, Sakane N, Ando H, Miyazaki R. Social participation and physical prefrailty in older Japanese adults: The Shimane CoHRE study. PLoS One. 2020 Dec 16;15(12):e0243548. doi: 10.1371/journal.pone.0243548. eCollection 2020. PMID: 33326452

  2. Sakai Y, Arie H, Ni Y, Zhuge F, Xu L, Chen G, Nagata N, Suzuki T, Kaneko S, Ota T, Nagashimada M. Lactobacillus pentosus strain S-PT84 improves steatohepatitis by maintaining gut permeability. J Endocrinol. 2020 Nov;247(2):169-181. doi: 10.1530/JOE-20-0105. PMID: 33032263

  3. Sakai Y, Chen G, Ni Y, Zhuge F, Xu L, Nagata N, Kaneko S, Ota T, Nagashimada M. DPP-4 Inhibition with Anagliptin Reduces Lipotoxicity-Induced Insulin Resistance and Steatohepatitis in Male Mice. Endocrinology. 2020 Oct 1;161(10):bqaa139. doi:10.1210/endocr/bqaa139. PMID: 32790863

  4. Fujiwara T, Ono M, Mieda M, Yoshikawa H, Nakata R, Daikoku T, Sekizuka-Kagami N, Maida Y, Ando H, Fujiwara H. Adolescent Dietary Habit-induced Obstetric and Gynecologic Disease (ADHOGD) as a New Hypothesis-Possible Involvement of Clock System. Nutrients. 2020 May 2;12(5):E1294. doi: 10.3390/nu12051294.

  5. Ni Y, Zhuge F, Nagashimada M, Nagata N, Xu L, Yamamoto S, Fuke N, Ushida Y, Suganuma H, Kaneko S, Ota T. Lycopene prevents the progression of lipotoxicity-induced nonalcoholic steatohepatitis by decreasing oxidative stress in mice. Free Radic Biol Med. 2020 May 20;152:571-582. doi: 10.1016/j.freeradbiomed.2019.11.036. Epub 2019 Nov 29.

  6. Okubo H, Ando H, Ishizuka K, Kitagawa R, Okubo S, Saito H, Kokubu S, Miyazaki A, Ikejima K, Shiina S, Nagahara A. Carnitine insufficiency is associated with fatigue during lenvatinib treatment in patients with hepatocellular carcinoma. PLoS One. 2020 Mar 3;15(3):e0229772. doi: 10.1371/journal.pone.0229772. eCollection 2020. PubMed PMID: 32126131; PubMed Central PMCID: PMC7053710.

  7. Nishikawa T, Nagata N, Shimakami T, Shirakura T, Matsui C, Ni Y, Zhuge F, Xu L, Chen G, Nagashimada M, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Honda M, Kaneko S, Ota T. Xanthine oxidase inhibition attenuates insulin resistance and diet-induced steatohepatitis in mice. Sci Rep. 2020 Jan 21;10(1):815. doi: 10.1038/s41598-020-57784-3. PubMed PMID: 31965018; PubMed Central PMCID: PMC6972756.

2019

  1. Suzuki C, Ushijima K, Ando H, Kitamura H, Horiguchi M, Akita T, Yamashita C,Fujimura A. Induction of Dbp by a histone deacetylase inhibitor is involved in amelioration of insulin sensitivity via adipocyte differentiation in ob/ob mice. Chronobiol Int. 2019 Jul;36(7):955-968. doi: 10.1080/07420528.2019.1602841. Epub 2019 May 9. PubMed PMID: 31070057.

  2. Sagawa E, Okubo H, Ando H, Sorin Y, Kanazawa R, Nakadera E, Fukada H, Kokubu S, Miyazaki A. Plasma concentration and efficacy of tolvaptan in cirrhotic patients with refractory ascites. J Pharmacol Sci. 2019 Apr;139(4):373-376. doi: 10.1016/j.jphs.2019.01.015. Epub 2019 Feb 27. PubMed PMID: 30857764.

  3. Arakawa Y, Ushijima K, Tsuchiya H, Morishige JI, Mii A, Ando H, Tsuruoka SI, Fujimura A. Influence of renal ischaemia-reperfusion injury on renal neutrophil gelatinase-associated lipocalin receptor (24p3R) in rats. Clin Exp Pharmacol Physiol. 2019 Dec;46(12):1166-1173. doi: 10.1111/1440-1681.13129. Epub 2019 Jul 23.

  4. Maeda A, Irie K, Ando H, Hasegawa A, Taniguchi H, Kadowaki S, Muro K, Tajika M, Aoki M, Inaguma K, Kajita M, Fujimura A, Fukushima S. Associations among regorafenib concentrations, severe adverse reactions, and ABCG2 and OATP1B1 polymorphisms. Cancer Chemother Pharmacol. 2019 Jan;83(1):107-113. doi: 10.1007/s00280-018-3710-9. Epub 2018 Oct 27. PubMed PMID: 30368586.

  5. Fuke N, Nagata N, Suganuma H, Ota T. Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors. Nutrients. 2019 Sep 23;11(10). pii: E2277. doi: 10.3390/nu11102277. Review. PubMed PMID: 31547555.

  6. Chen G, Ni Y, Nagata N, Xu L, Zhuge F, Nagashimada M, Kaneko S, Ota T. Pirfenidone prevents and reverses hepatic insulin resistance and steatohepatitis by polarizing M2 macrophages. Lab Invest. 2019 Sep;99(9):1335-1348. doi: 10.1038/s41374-019-0255-4. Epub 2019 Apr 24. PubMed PMID: 31019294.

  7. Chen G, Ni Y, Nagata N, Zhuge F, Xu L, Nagashimada M, Yamamoto S, Ushida Y, Fuke N, Suganuma H, Kaneko S, Ota T. Lycopene Alleviates Obesity-Induced Inflammation and Insulin Resistance by Regulating M1/M2 Status of Macrophages. Mol Nutr Food Res. 2019 Nov;63(21):e1900602. doi: 10.1002/mnfr.201900602. Epub 2019 Aug 22. PubMed PMID: 31408586.

  8. Ni Y, Zhuge F, Nagashimada M, Nagata N, Xu L, Yamamoto S, Fuke N, Ushida Y, Suganuma H, Kaneko S, Ota T. Lycopene prevents the progression of lipotoxicity-induced nonalcoholic steatohepatitis by decreasing oxidative stress in mice. Free Radic Biol Med. 2019 Nov 29. pii: S0891-5849(19)31604-1. doi: 10.1016/j.freeradbiomed.2019.11.036. [Epub ahead of print] PubMed PMID: 31790829.

  9. Xu L, Nagata N, Ota T. Impact of Glucoraphanin-Mediated Activation of Nrf2 on Non-Alcoholic Fatty Liver Disease with a Focus on Mitochondrial Dysfunction. Int J Mol Sci. 2019 Nov 25;20(23). pii: E5920. doi: 10.3390/ijms20235920. Review. PubMed PMID: 31775341; PubMed Central PMCID: PMC6929181.

  10. Xu L, Nagata N, Chen G, Nagashimada M, Zhuge F, Ni Y, Sakai Y, Kaneko S, Ota T. Empagliflozin reverses obesity and insulin resistance through fat browning and alternative macrophage activation in mice fed a high-fat diet. BMJ Open Diabetes Res Care. 2019 Oct 25;7(1):e000783. doi: 10.1136/bmjdrc-2019-000783. eCollection 2019. PubMed PMID: 31749970; PubMed Central PMCID: PMC6827766.

2018

  1. Fujiwara T, Nakata R, Ono M, Mieda M, Ando H, Daikoku T, Fujiwara H. Time Restriction of Food Intake During the Circadian Cycle Is a Possible Regulator of Reproductive Function in Postadolescent Female Rats. Curr Dev Nutr. 2018 Nov 26;3(4):nzy093. doi: 10.1093/cdn/nzy093. eCollection 2019 Apr. PubMed PMID: 30963143; PubMed Central PMCID: PMC6446981.

  2. Miyazaki R, Ando H, Hamasaki T, Higuchi Y, Oshita K, Tashiro T, Sakane N. Development and initial validation of the Morningness-Eveningness Exercise Preference Questionnaire (MEEPQ) in Japanese university students. PLoS One. 2018 Jul 18;13(7):e0200870. doi: 10.1371/journal.pone.0200870. eCollection 2018. PubMed PMID: 30021011; PubMed Central PMCID: PMC6051639.

  3. Okubo H, Ando H, Sorin Y, Nakadera E, Fukada H, Morishige J, Miyazaki A, Ikejima K. Gadoxetic acid-enhanced magnetic resonance imaging to predict paritaprevir-induced hyperbilirubinemia during treatment of hepatitis C. PLoS One. 2018 Apr 30;13(4):e0196747. doi: 10.1371/journal.pone.0196747. eCollection 2018. PubMed PMID: 29709031; PubMed Central PMCID: PMC5927452.

  4. Morishige J, Yamashita R, Tanaka T, Satouchi K. A Cleanup Method for Mass Spectrometric Analysis of Sphingosine- and Ceramide-1-Phosphate in Blood and Solid Tissue Using a Phosphate Capture Molecule. Methods Mol Biol. 2018;1697:57-71. doi: 10.1007/7651_2017_6. PubMed PMID: 28361484.

  5. Xu L, Nagata N, Ota T. Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance. Adipocyte. 2018;7(3):218-225. doi: 10.1080/21623945.2018.1474669. Epub 2018 Aug 9. PubMed PMID: 29898626.

  6. Shimada K, Ushijima K, Suzuki C, Horiguchi M, Ando H, Akita T, Shimamura M, Fujii J, Yamashita C, Fujimura A. Pulmonary administration of curcumin inhibits B16F10 melanoma lung metastasis and invasion in mice. Cancer Chemother Pharmacol. 2018 Aug;82(2):265-273. doi: 10.1007/s00280-018-3616-6. Epub 2018 Jun 4. PubMed PMID: 29869202.

  7. Yoshioka D, Ando H, Ushijima K, Kumazaki M, Fujimura A. Chronotherapy of maxacalcitol on skin inflammation induced by topical 12-O-tetradecanoylphorbol-13-acetate in mice. Chronobiol Int. 2018 Sep;35(9):1269-1280. doi: 10.1080/07420528.2018.1474890. Epub 2018 May 18. PubMed PMID: 29775091.

  8. Tsuchiya Y, Ushijima K, Noguchi T, Okada N, Hayasaka JI, Jinbu Y, Ando H, Mori Y, Kusama M, Fujimura A. Influence of a dosing-time on toxicities induced by docetaxel, cisplatin and 5-fluorouracil in patients with oral squamous cell carcinoma; a cross-over pilot study. Chronobiol Int. 2018 Feb;35(2):289-294. doi: 10.1080/07420528.2017.1392551. Epub 2017 Nov 16. PubMed PMID: 29144178.

  9. Xu L, Nagata N, Nagashimada M, Zhuge F, Ni Y, Chen G, Kamei J, Ishikawa H, Komatsu Y, Kaneko S, Ota T. A porcine placental extract prevents steatohepatitis by suppressing activation of macrophages and stellate cells in mice. Oncotarget. 2018 Feb 27;9(19):15047-15060. doi: 10.18632/oncotarget.24587. eCollection 2018 Mar 13. PubMed PMID: 29599925; PubMed Central PMCID: PMC5871096.

​2017

  1. Nagata N, Xu L, Kohno S, Ushida Y, Aoki Y, Umeda R, Fuke N, Zhuge F, Ni Y, Nagashimada M, Takahashi C, Suganuma H, Kaneko S, Ota T. Glucoraphanin ameliorates obesity and insulin resistance through adipose tissue browning and reduction of metabolic endotoxemia in mice. Diabetes. 2017 May;66(5):1222-1236. doi: 10.2337/db16-0662. Epub 2017 Feb 16. PubMed PMID: 28209760.

  2. Funaki M, Kitabayashi J, Shimakami T, Nagata N, Sakai Y, Takegoshi K, Okada H, Murai K, Shirasaki T, Oyama T, Yamashita T, Ota T, Takuwa Y, Honda M, Kaneko S. Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo. Sci Rep. 2017 Dec 5;7(1):16978. doi: 10.1038/s41598-017-17285-2. PubMed PMID: 29208982; PubMed Central PMCID: PMC5717167.

  3. Fujiwara Y, Ando H, Ushijima K, Horiguchi M, Yamashita C, Fujimura A. Dosing-time-dependent effect of rivaroxaban on coagulation activity in rats. J Pharmacol Sci. 2017 Aug;134(4):234-238. doi: 10.1016/j.jphs.2017.08.001. Epub 2017 Aug 12. PubMed PMID: 28844423.

  4. Xu L, Nagata N, Nagashimada M, Zhuge F, Ni Y, Chen G, Mayoux E, Kaneko S, Ota T. SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice. EBioMedicine. 2017 Jun;20:137-149. doi: 10.1016/j.ebiom.2017.05.028. Epub 2017 May 26. PubMed PMID: 28579299; PubMed Central PMCID: PMC5478253.

  5. Pongkan W, Takatori O, Ni Y, Xu L, Nagata N, Chattipakorn SC, Usui S, Kaneko S, Takamura M, Sugiura M, Chattipakorn N, Ota T. β-Cryptoxanthin exerts greater cardioprotective effects on cardiac ischemia-reperfusion injury than astaxanthin by attenuating mitochondrial dysfunction in mice. Mol Nutr Food Res. 2017 May 20. doi: 10.1002/mnfr.201601077. [Epub ahead of print] PubMed PMID: 28544535.

  6. Kapse S, Ando H, Fujiwara Y, Suzuki C, Ushijima K, Kitamura H, Hosohata K, Kotani K, Shimba S, Fujimura A. Effect of a dosing-time on quetiapine-induced acute hyperglycemia in mice. J Pharmacol Sci. 2017 Mar;133(3):139-145. doi: 10.1016/j.jphs.2017.02.008. Epub 2017 Feb 17. PubMed PMID: 28279595.

  7. Ushijima K, Ando H, Arakawa Y, Aizawa K, Suzuki C, Shimada K, Tsuruoka SI, Fujimura A. Prevention against renal damage in rats with subtotal nephrectomy by sacubitril/valsartan (LCZ696), a dual-acting angiotensin receptor-neprilysin inhibitor. Pharmacol Res Perspect. 2017 Aug;5(4):e00336. doi: 10.1002/prp2.336. PubMed PMID: 28805977.

  8. Maeda A, Ando H, Ura T, Komori A, Hasegawa A, Taniguchi H, Kadowaki S, Muro K, Tajika M, Kobara M, Matsuzaki M, Hashimoto N, Maeda M, Kojima Y, Aoki M, Kondo E, Mizutani A, Fujimura A. Association between and polymorphisms and adverse drug reactions to regorafenib: A preliminary study. Int J Clin Pharmacol Ther. 2017 May;55(5):409-415. doi: 10.5414/CP202788. PubMed PMID: 28157071.

  9. Maeda A, Ando H, Ura T, Muro K, Aoki M, Saito K, Kondo E, Takahashi S, Ito Y, Mizuno Y, Fujimura A. Differences in Urinary Renal Failure Biomarkers in Cancer Patients Initially Treated with Cisplatin. Anticancer Res. 2017 Sep;37(9):5235-5239. PubMed PMID: 28870959.

  10. Kotani K, Miyamoto M, Ando H. The effect of treatments for rheumatoid arthritis on endothelial dysfunction evaluated by flow-mediated vasodilation in patients with rheumatoid arthritis. Curr Vasc Pharmacol. 2017;15(1):10-18. PubMed PMID: 27739363.

  11. Okubo H, Kitamura T, Ando H, Fukada H, Igusa Y, Kokubu S, Miyazaki A, Fujimura A, Shiina S, Watanabe S. Gadoxetic Acid-Enhanced MR Imaging Predicts Simeprevir-Induced Hyperbilirubinemia During Hepatitis C Virus Treatment: A Pilot Study. J Clin Pharmacol. 2017 Mar;57(3):369-375. doi: 10.1002/jcph.811. Epub 2016 Sep 22. PubMed PMID: 27530761.

  12. Okada H, Takabatake R, Honda M, Takegoshi K, Yamashita T, Nakamura M, Shirasaki T, Sakai Y, Shimakami T, Nagata N, Takamura T, Tanaka T, Kaneko S. Peretinoin, an acyclic retinoid, suppresses steatohepatitis and tumorigenesis by activating autophagy in mice fed an atherogenic high-fat diet. Oncotarget. 2017 Jun 20;8(25):39978-39993. doi: 10.18632/oncotarget.18116. PubMed PMID: 28591717; PubMed Central PMCID: PMC5522259.

​2016

  1. Ando H, Ushijima K, Shimba S, Fujimura A. Daily Fasting Blood Glucose Rhythm in Male Mice: A Role of the Circadian Clock in the Liver. Endocrinology. 2016 Feb;157(2):463-9. doi: 10.1210/en.2015-1376. PubMed PMID: 26653333.

  2. Ando H, Nakano K, Ushijima K, Kurokawa S, Washino S, Hosohata K, Morita T, Fujimura A. Influence of genetic polymorphisms of multidrug and toxin extrusion protein 1 on its mRNA expression in peripheral blood cells. J Pharmacol Sci. 2016 Jun;131(2):138-40. doi: 10.1016/j.jphs.2016.03.002. PubMed PMID: 27025966.

  3. Hosohata K, Washino S, Kubo T, Natsui S, Fujisaki A, Kurokawa S, Ando H, Fujimura A, Morita T. Early prediction of cisplatin-induced nephrotoxicity by urinary vanin-1 in patients with urothelial carcinoma. Toxicology. 2016 Jun 1;359-360:71-5. doi: 10.1016/j.tox.2016.06.011. PubMed PMID: 27317936.

  4. Hosohata K, Yoshioka D, Tanaka A, Ando H, Fujimura A. Early urinary biomarkers for renal tubular damage in spontaneously hypertensive rats on a high salt intake. Hypertens Res. 2016 Jan;39(1):19-26. doi: 10.1038/hr.2015.103. PubMed PMID: 26376947.

  5. Chen G, Ni Y, Nagata N, Xu L, Ota T. Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease. Int J Mol Sci. 2016 Aug 23;17(9). pii: E1379. doi: 10.3390/ijms17091379. Review. PubMed PMID: 27563875; PubMed Central PMCID: PMC5037659.

  6. Zhuge F, Ni Y, Nagashimada M, Nagata N, Xu L, Mukaida N, Kaneko S, Ota T. DPP-4 Inhibition by Linagliptin Attenuates Obesity-Related Inflammation and Insulin Resistance by Regulating M1/M2 Macrophage Polarization. Diabetes. 2016 Oct;65(10):2966-79. doi: 10.2337/db16-0317. PubMed PMID: 27445264.

  7. Kimura K, Tanida M, Nagata N, Inaba Y, Watanabe H, Nagashimada M, Ota T, Asahara S, Kido Y, Matsumoto M, Toshinai K, Nakazato M, Shibamoto T, Kaneko S, Kasuga M, Inoue H. Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor. Cell Rep. 2016 Mar 15;14(10):2362-74. doi: 10.1016/j.celrep.2016.02.032. PubMed PMID: 26947072.