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研究業績（英語論文）

2024

  1. Xu P, Morishige JI, Jing Z, Nagata N, Shi Y, Iba T, Daikoku T, Ono M, Maida Y, Fujiwara T, Fujiwara H, Ando H. Exenatide administration time-dependently affects the hepatic circadian clock through glucagon-like peptide-1 receptors in the central nervous system. Biochem Pharmacol. 2024 Oct 4:116567. doi: 10.1016/j.bcp.2024.116567. Online ahead of print. PMID: 39369911

  2. Chen Y, Hosono T, Ono M, Daikoku T, Toyoda N, Nomura S, Kagami K, Orisaka S, Horike SI, Shi Y, Xu P, Morishige JI, Fujiwara T, Fujiwara H, Ando H. Comparison of the effects of inappropriate meal timing-induced and genetic models of circadian clock disruption on uterine mRNA expression profiles. J Nutr, in press

  3. Okubo H, Ando H, Nakamura S, Takasaki Y, Ito K, Fukuo Y, Ikejima K, Isayama H. Real world data of cabozantinib in patients with hepatocellular carcinoma: Focusing on dose setting and modification. Cancer Med. 2024 Sep;13(18):e70222. doi: 10.1002/cam4.70222.

  4. Ono M, Hayashizaki Y, Orihara S, Kitamizu M, Hamada C, Yamaguchi M, Kikuchi T, Kawamura T, Yamanaka A, Ueno K, Kojima J, Fujiwara T, Daikoku T, Maida Y, Ando H, Fujiwara H, Oshima K, Kuji N, Nishi H. Impact of daily breakfast intake on the outcomes of assisted reproductive technology procedures. Nutrition. 2024 Aug 14;127:112555. doi: 10.1016/j.nut.2024.112555. PMID: 39226629

  5. Chen G, Yu Y, Zhu Y, Nagashimada M, Wang Y, Nagata N, Xu L. Cenicriviroc Suppresses and Reverses Steatohepatitis by Regulating Macrophage Infiltration and M2 Polarization in Mice. Endocrinology. 2024 May 27;165(7):bqae069. doi: 10.1210/endocr/bqae069. PMID: 38862137

  6. Kawamura T, Dai Y, Ono M, Kikuchi T, Yamanaka A, Ueno K, Kojima J, Fujiwara T, Daikoku T, Maida Y, Ando H, Fujiwara H, Kuji N, Nishi H. BMAL1 positively correlates with genes regulating steroidogenesis in human luteinized granulosa cells. Reproduction. 2024 Jan 23;167(2):e230225. doi: 10.1530/REP-23-0225. Print 2024 Feb 1. PMID: 38271820

  7. Tsumita T, Takeda R, Maishi N, Hida Y, Sasaki M, Orba Y, Sato A, Toba S, Ito W, Teshirogi T, Sakurai Y, Iba T, Naito H, Ando H, Watanabe H, Mizuno A, Nakanishi T, Matsuda A, Zixiao R, Lee JW, Iimura T, Sawa H, Hida K. Viral uptake and pathophysiology of the lung endothelial cells in age-associated severe SARS-CoV-2 infection models. Aging Cell. 2024 Feb;23(2):e14050. doi: 10.1111/acel.14050. Epub 2023 Dec 14. PMID: 38098255 

  8. Abuduyimiti T, Goto H, Kimura K, Oshima Y, Tanida R, Kamoshita K, Leerach N, Abuduwaili H, Oo HK, Li Q, Galicia-Medina CM, Takayama H, Ishii KA, Nakano Y, Takeshita Y, Iba T, Naito H, Honda M, Harada K, Yamamoto Y, Takamura T. Diabetes accelerates steatohepatitis in mice: liver pathology and single-cell gene expression signatures. Am J Pathol. 2024 Feb 1:S0002-9440(24)00037-3. doi: 10.1016/j.ajpath.2024.01.007. Online ahead of print.

2023

  1. Jing Z, Iba T, Naito H, Xu P, Morishige JI, Nagata N, Okubo H, Ando H. L-Carnitine prevents lenvatinib-induced muscle toxicity without impairment of the anti-angiogenic efficacy. Front Pharmacol. 2023 Apr 6;14:1182788. doi: 10.3389/fphar.2023.1182788. eCollection 2023. PMID: 37089945

  2. Morishige JI, Yoshioka K, Nakata H, Ishimaru K, Nagata N, Tanaka T, Takuwa Y, Ando H.  Sphingosine Kinase 1 is Involved in Triglyceride Breakdown by Maintaining Lysosomal Integrity in Brown Adipocytes. J Lipid Res. 2023 Sep 24:100450. doi: 10.1016/j.jlr.2023.100450. Online ahead of print.PMID: 37751791

  3. Miura K, Morishige JI, Abe J, Xu P, Shi Y, Jing Z, Nagata N, Miyazaki R, Sakane N, Mieda M, Ono M, Maida Y, Fujiwara T, Fujiwara H, Ando H. Imeglimin profoundly affects the circadian clock in mouse embryonic fibroblasts. J Pharmacol Sci. 2023 Dec;153(4):215-220. doi: 10.1016/j.jphs.2023.10.001. Epub 2023 Oct 13. PMID: 37973219

  4. Nomura S, Hosono T, Ono M, Daikoku T, Mieda M, Kagami K, Iizuka T, Chen Y, Shi Y, Morishige JI, Fujiwara T, Fujiwara H, Ando H. Desynchronization between food intake and light stimulations induces uterine clock quiescence in female mice. J Nutr. 2023 Jun 17:S0022-3166(23)72424-3. doi: 10.1016/j.tjnut.2023.06.018. Online ahead of print. PMID: 37336322

  5. Ando H. Inhibition of aldosterone synthase: Does this offer advantages compared with the blockade of mineralocorticoid receptors? Hypertens Res. 2023 Apr;46(4):1056-1057. doi: 10.1038/s41440-023-01188-z. Epub 2023 Jan 18.PMID: 36653520

  6. Ono M, Ando H, Daikoku T, Fujiwara T, Mieda M, Mizumoto Y, Iizuka T, Kagami K, Hosono T, Nomura S, Toyoda N, Sekiuka-Kagami N, Maida Y, Kuji N, Nishi H, Fujiwara H. The Circadian Clock, Nutritional Signals and Reproduction: A Close Relationship. Int J Mol Sci. 2023; 24(2):1545. doi.org/10.3390/ijms24021545.

  7. Maeda A, Ando H, Irie K, Hashimoto N, Morishige JI, Fukushima S, Ebi H, Uchida K, Okada A, Iwata H, Sawaki M. Effects of ABCB1 and ABCG2 polymorphisms on the pharmacokinetics of abemaciclib metabolites (M2, M20, M18). Anticancer Res. 2023 Mar;43(3):1283-1289. doi: 10.21873/anticanres.16275. PMID: 36854511

  8. Sako S, Takeshita Y, Takayama H, Goto H, Nakano Y, Ando H, Tsujiguchi H, Yamashita T, Arai K, Kaneko S, Nakamura H, Harada K, Honda M, Takamura T. Trajectories of liver fibrosis and gene expression profiles in NAFLD associated with diabetes. Diabetes. 2023 Sep 1;72(9):1297-1306. doi: 10.2337/db22-0933.PMID: 37343270

  9. Miyazaki R, Abe T, Sakane N, Ando H, Yano S, Okuyama K,  Isomura M, Yamasaki M, Nabika T. Associtations between dairy consumption and the physical function in Japanese community-dwelling older adults: The Shimane CoHRE study. Geriatr Nurs. 2023 Sep-Oct;53:19-24. doi: 10.1016/j.gerinurse.2023.06.014. Epub 2023 Jul 3.PMID: 37406501

  10. Rahmawati FN, Iba T, Naito H, Shimizu S, Konishi H, Jia W, Takakura N. Single-cell sequencing reveals the existence of fetal vascular endothelial stem cell-like cells in mouse liver. Rahmawati FN, Iba T, Naito H, Shimizu S, Konishi H, Jia W, Takakura N. Stem Cell Res Ther. 2023 Aug 30;14(1):227. doi: 10.1186/s13287-023-03460-y. PMID: 37649114

  11. Shimizu S, Iba T, Naito H, Rahmawati FN, Konishi H, Jia W, Muramatsu F, Takakura N. Aging impairs the ability of vascular endothelial stem cells to generate endothelial cells in mice. Angiogenesis. 2023 Nov;26(4):567-580. doi: 10.1007/s10456-023-09891-8. Epub 2023 Aug 10.PMID: 37563497

  12. Promsuwan S, Sawamoto K, Xu L, Nagashimada M, Nagata N, Takiyama Y. A natural Nrf2 activator glucoraphanin improves hepatic steatosis in high-fat diet-induced obese male mice associated with AMPK activation. Diabetol Int. 2023 Aug 29;15(1):86-98. doi: 10.1007/s13340-023-00658-6. eCollection 2024 Jan. PMID: 38264234

2022

  1. Jing Z, Okubo H, Morishige JI, Xu P, Hasan N, Nagata N, Ando H. Lenvatinib causes reduced expression of carnitine/organic cation transporter 2 and carnitine deficiency in the skeletal muscle of rats. Toxicol Lett. 2022 Jul 3;366:17-25. doi: 10.1016/j.toxlet.2022.06.012. PMID: 35788046

  2. Ando H, Nagata N, Hosono T, Hasan N, Morishige JI, Daikoku T, Maida Y, Ono M, Fujiwara T, Fujiwara H. Sustained effect of habitual feeding time on daily rhythm of core body temperature in mice. Front Nutr. 2022 Aug 22;9:966788. doi: 10.3389/fnut.2022.966788. eCollection 2022. PMID: 36071943

  3. Hasan N, Sugimoto K, Yamada K, Morishige JI, Ushijima K, Fujimura A, Nagata N, Ando H. Chronic Treatment with Metformin Has No Disrupting Effect on the Hepatic Circadian Clock in Mice. Medicina (Kaunas). 2022 Feb 15;58(2):293. doi: 10.3390/medicina58020293.

  4. Nagata N, Chen G, Xu L, Ando H. An update of the chemokine system in the development of NAFLD. Medicina 2022 58(6):761.

  5. Okubo H, Ando H, Ishizuka K, Morishige JI, Ikejima K, Shiina S, Nagahara A. Impact of genetic polymorphisms on the pharmacokinetics and pharmacodynamics of lenvatinib in patients with hepatocellular carcinoma. J Pharmacol Sci. 2022 148(1):6-13.

  6. Okubo H, Ando H, Takasaki Y, Nakadera E, Fukuo Y, Shiina S, Ikejima K. Impact of Cabozantinib Exposure on Proteinuria and Muscle Toxicity in Patients with Unresectable Hepatocellular Carcinoma. Pharmaceuticals (Basel). 2022 Nov 25;15(12):1460. doi: 10.3390/ph15121460. PMID: 36558911

  7. Maeda A, Ando H, Irie K, Hashimoto N, Morishige JI, Fukushima S, Okada A, Ebi H, Matsuzaki M, Iwata H, Sawaki M. Effects of ABCB1 and ABCG2 polymorphisms on the pharmacokinetics of abemaciclib. Eur J Clin Pharmacol. 2022 Aug;78(8):1239-1247. doi: 10.1007/s00228-022-03331-0. Epub 2022 May 9. PMID: 35527301

  8. Miyazaki R, Ando H, Ayabe M, Hamasaki T, Higuchi Y, Oshita K, Sakane N. The CLOCK 3111T/C polymorphism is associated with hour-by-hour physical activity levels only on weekends among Japanese male and female university students. Physiol Behav. 2022 Apr 1;247:113705. doi: 10.1016/j.physbeh.2022.113705. Epub 2022 Jan 13. PMID: 3503249

  9. Ni Y, Zhuge F, Ni L, Nagata N, Yamashita T, Mukaida N, Kaneko S, Ota T, Nagashimada M. CX3CL1/CX3CR1 interaction protects against lipotoxicity-induced nonalcoholic steatohepatitis by regulating macrophage migration and M1/M2 status. Metabolism. 2022 Nov;136:155272. doi: 10.1016/j.metabol.2022.155272. Epub 2022 Jul 29.

  10. Okubo H, Atsukawa M, Okubo T, Ando H, Nakadera E, Ikejima K, Nagahara A. Gadoxetic acid-enhanced magnetic resonance imaging predicts hyperbilirubinemia induced by glecaprevir during hepatitis C virus treatment. Sci Rep. 2022 May 12;12(1):7847. doi: 10.1038/s41598-022-11707-6. PMID: 35552472

  11. Shirasaki T, Yamagoe S, Shimakami T, Murai K, Imamura R, Ishii KA, Takayama H, Matsumoto Y, Tajima-Shirasaki N, Nagata N, Shimizu R, Yamanaka S, Abe A, Omura H, Kawaguchi K, Okada H, Yamashita T, Yoshikawa T, Takimoto K, Taharaguchi M, Takatsuka S, Miyazaki Y, Tamai T, Tanabe Y, Kurachi M, Yamamoto Y, Kaneko S, Matsumoto K, Takamura T, Honda M. Leukocyte cell-derived chemotaxin 2 is an antiviral regulator acting through the proto-oncogene MET. Nat Commun. 2022 Jun 8;13(1):3176. doi: 10.1038/s41467-022-30879-3. PMID: 35676290

  12. Miyazaki R, Abe T, Yano S, Okuyama K, Sakane N, Ando H, Isomura M, Yamasaki M, Nabika T. Associations between physical frailty and living arrangements in Japanese older adults living in a rural remote island: The Shimane CoHRE study. J Gen Fam Med 2022 Apr 10;23(5):310-318. doi: 10.1002/jgf2.544. eCollection 2022 Sep. PMID: 36093222

  13. Ono M, Toyoda N, Kagami K, Hosono T, Matsumoto T, Horike SI, Yamazaki R, Nakamura M, Mizumoto Y, Fujiwara T, Ando H, Fujiwara H, Daikoku T. Uterine deletion of Bmal1 impairs placental vascularization and induces intrauterine fetal death in mice. Int J Mol Sci. 2022 Jul 11;23(14):7637. doi: 10.3390/ijms23147637. PMID: 35886985

2021

  1. Hasan N, Nagata N, Morishige J, Islam MT, Jing Z, Harada K, Mieda M, Ono M, Fujiwara H, Daikoku T, Fujiwara T, Maida Y, Ota T, Shimba S, Kaneko S, Fujimura A, Ando H. Brown adipocyte-specific knockout of Bmal1 causes mild but significant impairment of thermogenesis in mice. Mol Metab. 2021 Jul;49:101202. doi: 10.1016/j.molmet.2021.101202. Epub 2021 Mar 3. PMID: 33676029

  2. Nagata N, Kawasumi M, Fujimura A, Ando H. Edoxaban dosing time affects blood coagulation inhibition in rats. TH Open. 2021 Apr 14;5(2):e107-e112. doi: 10.1055/s-0041-1725041. eCollection 2021 Apr. PMID: 33870074

  3. Okubo H, Ando H, Nakadera E, Ikejima K, Shiina S, Nagahara A. Levocarnitine supplementation suppresses lenvatinib-related sarcopenia in hepatocellular carcinoma patients: results of a propensity score analysis. Nutrients 2021, 13(12), 4428; https://doi.org/10.3390/nu13124428.

  4. Hosono T, Ono M, Daikoku T, Mieda M, Nomura S, Kagami K, Iizuka T, Nakata R, Fujiwara T, Fujiwara H, Ando H. Time-Restricted Feeding Regulates Circadian Rhythm of Murine Uterine Clock. Curr Dev Nutr. 2021 Apr 9;5(5):nzab064. doi: 10.1093/cdn/nzab064. eCollection 2021 May. PMID: 33981944

  5. Xu L, Chen Y, Nagashimada M, Ni Y, Zhuge F, Chen G, Li H, Pan T, Yamashita T, Mukaida N, Kaneko S, Ota T, Nagata N. CC chemokine ligand 3 deficiency ameliorates diet-induced steatohepatitis by regulating liver macrophage recruitment and M1/M2 status in mice. Metabolism. 2021 Oct 14;125:154914. doi: 10.1016/j.metabol.2021.154914. PMID: 34656648

  6. Maeda A, Irie K, Hashimoto N, Fukushima S, Ando H, Okada A, Ebi H, Kajita M, Iwata H, Sawaki M. Serum concentration of the CKD4/6 inhibitor abemaciclib, but not of creatinine, strongly predicts hematological adverse events in patients with breast cancer: a preliminary report. Invest New Drugs. 2021 Feb;39(1):272-277. doi: 10.1007/s10637-020-00994-3. Epub 2020 Aug 27.PMID: 32856274

  7. Ali H, Yamashita R, Morishige JI, Morito K, Kakiuchi N, Hayashi J, Aihara M, Kawakami R, Tsuchiya K, Tanaka T. Mass Spectrometric Analysis of Sphingomyelin with N-α-Hydroxy Fatty Acyl Residue in Mouse Tissues. Lipids. 2021 Mar;56(2):181-188. doi: 10.1002/lipd.12285. Epub 2020 Sep 30. PMID: 32996178

  8. Nagashimada M, Sawamoto K, Ni Y, Kitade H, Nagata N, Xu L, Kobori M, Mukaida N, Yamashita T, Kaneko S, Ota T. CX3CL1-CX3CR1 Signaling Deficiency Exacerbates Obesity-induced Inflammation and Insulin Resistance in Male Mice. Endocrinology. 2021 Jun 1;162(6):bqab064. doi: 10.1210/endocr/bqab064. PMID: 33765141

2020​

  1. Abe T, Okuyama K, Kamada M, Yano S, Toyama Y, Isomura M, Nabika T, Sakane N, Ando H, Miyazaki R. Social participation and physical prefrailty in older Japanese adults: The Shimane CoHRE study. PLoS One. 2020 Dec 16;15(12):e0243548. doi: 10.1371/journal.pone.0243548. eCollection 2020. PMID: 33326452

  2. Sakai Y, Arie H, Ni Y, Zhuge F, Xu L, Chen G, Nagata N, Suzuki T, Kaneko S, Ota T, Nagashimada M. Lactobacillus pentosus strain S-PT84 improves steatohepatitis by maintaining gut permeability. J Endocrinol. 2020 Nov;247(2):169-181. doi: 10.1530/JOE-20-0105. PMID: 33032263

  3. Sakai Y, Chen G, Ni Y, Zhuge F, Xu L, Nagata N, Kaneko S, Ota T, Nagashimada M. DPP-4 Inhibition with Anagliptin Reduces Lipotoxicity-Induced Insulin Resistance and Steatohepatitis in Male Mice. Endocrinology. 2020 Oct 1;161(10):bqaa139. doi:10.1210/endocr/bqaa139. PMID: 32790863

  4. Fujiwara T, Ono M, Mieda M, Yoshikawa H, Nakata R, Daikoku T, Sekizuka-Kagami N, Maida Y, Ando H, Fujiwara H. Adolescent Dietary Habit-induced Obstetric and Gynecologic Disease (ADHOGD) as a New Hypothesis-Possible Involvement of Clock System. Nutrients. 2020 May 2;12(5):E1294. doi: 10.3390/nu12051294.

  5. Ni Y, Zhuge F, Nagashimada M, Nagata N, Xu L, Yamamoto S, Fuke N, Ushida Y, Suganuma H, Kaneko S, Ota T. Lycopene prevents the progression of lipotoxicity-induced nonalcoholic steatohepatitis by decreasing oxidative stress in mice. Free Radic Biol Med. 2020 May 20;152:571-582. doi: 10.1016/j.freeradbiomed.2019.11.036. Epub 2019 Nov 29.

  6. Okubo H, Ando H, Ishizuka K, Kitagawa R, Okubo S, Saito H, Kokubu S, Miyazaki A, Ikejima K, Shiina S, Nagahara A. Carnitine insufficiency is associated with fatigue during lenvatinib treatment in patients with hepatocellular carcinoma. PLoS One. 2020 Mar 3;15(3):e0229772. doi: 10.1371/journal.pone.0229772. eCollection 2020. PubMed PMID: 32126131; PubMed Central PMCID: PMC7053710.

  7. Nishikawa T, Nagata N, Shimakami T, Shirakura T, Matsui C, Ni Y, Zhuge F, Xu L, Chen G, Nagashimada M, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Honda M, Kaneko S, Ota T. Xanthine oxidase inhibition attenuates insulin resistance and diet-induced steatohepatitis in mice. Sci Rep. 2020 Jan 21;10(1):815. doi: 10.1038/s41598-020-57784-3. PubMed PMID: 31965018; PubMed Central PMCID: PMC6972756.

2019

  1. Suzuki C, Ushijima K, Ando H, Kitamura H, Horiguchi M, Akita T, Yamashita C,Fujimura A. Induction of Dbp by a histone deacetylase inhibitor is involved in amelioration of insulin sensitivity via adipocyte differentiation in ob/ob mice. Chronobiol Int. 2019 Jul;36(7):955-968. doi: 10.1080/07420528.2019.1602841. Epub 2019 May 9. PubMed PMID: 31070057.

  2. Sagawa E, Okubo H, Ando H, Sorin Y, Kanazawa R, Nakadera E, Fukada H, Kokubu S, Miyazaki A. Plasma concentration and efficacy of tolvaptan in cirrhotic patients with refractory ascites. J Pharmacol Sci. 2019 Apr;139(4):373-376. doi: 10.1016/j.jphs.2019.01.015. Epub 2019 Feb 27. PubMed PMID: 30857764.

  3. Arakawa Y, Ushijima K, Tsuchiya H, Morishige JI, Mii A, Ando H, Tsuruoka SI, Fujimura A. Influence of renal ischaemia-reperfusion injury on renal neutrophil gelatinase-associated lipocalin receptor (24p3R) in rats. Clin Exp Pharmacol Physiol. 2019 Dec;46(12):1166-1173. doi: 10.1111/1440-1681.13129. Epub 2019 Jul 23.

  4. Maeda A, Irie K, Ando H, Hasegawa A, Taniguchi H, Kadowaki S, Muro K, Tajika M, Aoki M, Inaguma K, Kajita M, Fujimura A, Fukushima S. Associations among regorafenib concentrations, severe adverse reactions, and ABCG2 and OATP1B1 polymorphisms. Cancer Chemother Pharmacol. 2019 Jan;83(1):107-113. doi: 10.1007/s00280-018-3710-9. Epub 2018 Oct 27. PubMed PMID: 30368586.

  5. Fuke N, Nagata N, Suganuma H, Ota T. Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors. Nutrients. 2019 Sep 23;11(10). pii: E2277. doi: 10.3390/nu11102277. Review. PubMed PMID: 31547555.

  6. Chen G, Ni Y, Nagata N, Xu L, Zhuge F, Nagashimada M, Kaneko S, Ota T. Pirfenidone prevents and reverses hepatic insulin resistance and steatohepatitis by polarizing M2 macrophages. Lab Invest. 2019 Sep;99(9):1335-1348. doi: 10.1038/s41374-019-0255-4. Epub 2019 Apr 24. PubMed PMID: 31019294.

  7. Chen G, Ni Y, Nagata N, Zhuge F, Xu L, Nagashimada M, Yamamoto S, Ushida Y, Fuke N, Suganuma H, Kaneko S, Ota T. Lycopene Alleviates Obesity-Induced Inflammation and Insulin Resistance by Regulating M1/M2 Status of Macrophages. Mol Nutr Food Res. 2019 Nov;63(21):e1900602. doi: 10.1002/mnfr.201900602. Epub 2019 Aug 22. PubMed PMID: 31408586.

  8. Xu L, Nagata N, Ota T. Impact of Glucoraphanin-Mediated Activation of Nrf2 on Non-Alcoholic Fatty Liver Disease with a Focus on Mitochondrial Dysfunction. Int J Mol Sci. 2019 Nov 25;20(23). pii: E5920. doi: 10.3390/ijms20235920. Review. PubMed PMID: 31775341; PubMed Central PMCID: PMC6929181.

  9. Xu L, Nagata N, Chen G, Nagashimada M, Zhuge F, Ni Y, Sakai Y, Kaneko S, Ota T. Empagliflozin reverses obesity and insulin resistance through fat browning and alternative macrophage activation in mice fed a high-fat diet. BMJ Open Diabetes Res Care. 2019 Oct 25;7(1):e000783. doi: 10.1136/bmjdrc-2019-000783. eCollection 2019. PubMed PMID: 31749970; PubMed Central PMCID: PMC6827766.

2018

  1. Fujiwara T, Nakata R, Ono M, Mieda M, Ando H, Daikoku T, Fujiwara H. Time Restriction of Food Intake During the Circadian Cycle Is a Possible Regulator of Reproductive Function in Postadolescent Female Rats. Curr Dev Nutr. 2018 Nov 26;3(4):nzy093. doi: 10.1093/cdn/nzy093. eCollection 2019 Apr. PubMed PMID: 30963143; PubMed Central PMCID: PMC6446981.

  2. Miyazaki R, Ando H, Hamasaki T, Higuchi Y, Oshita K, Tashiro T, Sakane N. Development and initial validation of the Morningness-Eveningness Exercise Preference Questionnaire (MEEPQ) in Japanese university students. PLoS One. 2018 Jul 18;13(7):e0200870. doi: 10.1371/journal.pone.0200870. eCollection 2018. PubMed PMID: 30021011; PubMed Central PMCID: PMC6051639.

  3. Okubo H, Ando H, Sorin Y, Nakadera E, Fukada H, Morishige J, Miyazaki A, Ikejima K. Gadoxetic acid-enhanced magnetic resonance imaging to predict paritaprevir-induced hyperbilirubinemia during treatment of hepatitis C. PLoS One. 2018 Apr 30;13(4):e0196747. doi: 10.1371/journal.pone.0196747. eCollection 2018. PubMed PMID: 29709031; PubMed Central PMCID: PMC5927452.

  4. Morishige J, Yamashita R, Tanaka T, Satouchi K. A Cleanup Method for Mass Spectrometric Analysis of Sphingosine- and Ceramide-1-Phosphate in Blood and Solid Tissue Using a Phosphate Capture Molecule. Methods Mol Biol. 2018;1697:57-71. doi: 10.1007/7651_2017_6. PubMed PMID: 28361484.

  5. Xu L, Nagata N, Ota T. Glucoraphanin: a broccoli sprout extract that ameliorates obesity-induced inflammation and insulin resistance. Adipocyte. 2018;7(3):218-225. doi: 10.1080/21623945.2018.1474669. Epub 2018 Aug 9. PubMed PMID: 29898626.

  6. Shimada K, Ushijima K, Suzuki C, Horiguchi M, Ando H, Akita T, Shimamura M, Fujii J, Yamashita C, Fujimura A. Pulmonary administration of curcumin inhibits B16F10 melanoma lung metastasis and invasion in mice. Cancer Chemother Pharmacol. 2018 Aug;82(2):265-273. doi: 10.1007/s00280-018-3616-6. Epub 2018 Jun 4. PubMed PMID: 29869202.

  7. Yoshioka D, Ando H, Ushijima K, Kumazaki M, Fujimura A. Chronotherapy of maxacalcitol on skin inflammation induced by topical 12-O-tetradecanoylphorbol-13-acetate in mice. Chronobiol Int. 2018 Sep;35(9):1269-1280. doi: 10.1080/07420528.2018.1474890. Epub 2018 May 18. PubMed PMID: 29775091.

  8. Tsuchiya Y, Ushijima K, Noguchi T, Okada N, Hayasaka JI, Jinbu Y, Ando H, Mori Y, Kusama M, Fujimura A. Influence of a dosing-time on toxicities induced by docetaxel, cisplatin and 5-fluorouracil in patients with oral squamous cell carcinoma; a cross-over pilot study. Chronobiol Int. 2018 Feb;35(2):289-294. doi: 10.1080/07420528.2017.1392551. Epub 2017 Nov 16. PubMed PMID: 29144178.

  9. Xu L, Nagata N, Nagashimada M, Zhuge F, Ni Y, Chen G, Kamei J, Ishikawa H, Komatsu Y, Kaneko S, Ota T. A porcine placental extract prevents steatohepatitis by suppressing activation of macrophages and stellate cells in mice. Oncotarget. 2018 Feb 27;9(19):15047-15060. doi: 10.18632/oncotarget.24587. eCollection 2018 Mar 13. PubMed PMID: 29599925; PubMed Central PMCID: PMC5871096.

​2017

  1. Nagata N, Xu L, Kohno S, Ushida Y, Aoki Y, Umeda R, Fuke N, Zhuge F, Ni Y, Nagashimada M, Takahashi C, Suganuma H, Kaneko S, Ota T. Glucoraphanin ameliorates obesity and insulin resistance through adipose tissue browning and reduction of metabolic endotoxemia in mice. Diabetes. 2017 May;66(5):1222-1236. doi: 10.2337/db16-0662. Epub 2017 Feb 16. PubMed PMID: 28209760.

  2. Funaki M, Kitabayashi J, Shimakami T, Nagata N, Sakai Y, Takegoshi K, Okada H, Murai K, Shirasaki T, Oyama T, Yamashita T, Ota T, Takuwa Y, Honda M, Kaneko S. Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo. Sci Rep. 2017 Dec 5;7(1):16978. doi: 10.1038/s41598-017-17285-2. PubMed PMID: 29208982; PubMed Central PMCID: PMC5717167.

  3. Fujiwara Y, Ando H, Ushijima K, Horiguchi M, Yamashita C, Fujimura A. Dosing-time-dependent effect of rivaroxaban on coagulation activity in rats. J Pharmacol Sci. 2017 Aug;134(4):234-238. doi: 10.1016/j.jphs.2017.08.001. Epub 2017 Aug 12. PubMed PMID: 28844423.

  4. Xu L, Nagata N, Nagashimada M, Zhuge F, Ni Y, Chen G, Mayoux E, Kaneko S, Ota T. SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice. EBioMedicine. 2017 Jun;20:137-149. doi: 10.1016/j.ebiom.2017.05.028. Epub 2017 May 26. PubMed PMID: 28579299; PubMed Central PMCID: PMC5478253.

  5. Pongkan W, Takatori O, Ni Y, Xu L, Nagata N, Chattipakorn SC, Usui S, Kaneko S, Takamura M, Sugiura M, Chattipakorn N, Ota T. β-Cryptoxanthin exerts greater cardioprotective effects on cardiac ischemia-reperfusion injury than astaxanthin by attenuating mitochondrial dysfunction in mice. Mol Nutr Food Res. 2017 May 20. doi: 10.1002/mnfr.201601077. [Epub ahead of print] PubMed PMID: 28544535.

  6. Kapse S, Ando H, Fujiwara Y, Suzuki C, Ushijima K, Kitamura H, Hosohata K, Kotani K, Shimba S, Fujimura A. Effect of a dosing-time on quetiapine-induced acute hyperglycemia in mice. J Pharmacol Sci. 2017 Mar;133(3):139-145. doi: 10.1016/j.jphs.2017.02.008. Epub 2017 Feb 17. PubMed PMID: 28279595.

  7. Ushijima K, Ando H, Arakawa Y, Aizawa K, Suzuki C, Shimada K, Tsuruoka SI, Fujimura A. Prevention against renal damage in rats with subtotal nephrectomy by sacubitril/valsartan (LCZ696), a dual-acting angiotensin receptor-neprilysin inhibitor. Pharmacol Res Perspect. 2017 Aug;5(4):e00336. doi: 10.1002/prp2.336. PubMed PMID: 28805977.

  8. Maeda A, Ando H, Ura T, Komori A, Hasegawa A, Taniguchi H, Kadowaki S, Muro K, Tajika M, Kobara M, Matsuzaki M, Hashimoto N, Maeda M, Kojima Y, Aoki M, Kondo E, Mizutani A, Fujimura A. Association between and polymorphisms and adverse drug reactions to regorafenib: A preliminary study. Int J Clin Pharmacol Ther. 2017 May;55(5):409-415. doi: 10.5414/CP202788. PubMed PMID: 28157071.

  9. Maeda A, Ando H, Ura T, Muro K, Aoki M, Saito K, Kondo E, Takahashi S, Ito Y, Mizuno Y, Fujimura A. Differences in Urinary Renal Failure Biomarkers in Cancer Patients Initially Treated with Cisplatin. Anticancer Res. 2017 Sep;37(9):5235-5239. PubMed PMID: 28870959.

  10. Kotani K, Miyamoto M, Ando H. The effect of treatments for rheumatoid arthritis on endothelial dysfunction evaluated by flow-mediated vasodilation in patients with rheumatoid arthritis. Curr Vasc Pharmacol. 2017;15(1):10-18. PubMed PMID: 27739363.

  11. Okubo H, Kitamura T, Ando H, Fukada H, Igusa Y, Kokubu S, Miyazaki A, Fujimura A, Shiina S, Watanabe S. Gadoxetic Acid-Enhanced MR Imaging Predicts Simeprevir-Induced Hyperbilirubinemia During Hepatitis C Virus Treatment: A Pilot Study. J Clin Pharmacol. 2017 Mar;57(3):369-375. doi: 10.1002/jcph.811. Epub 2016 Sep 22. PubMed PMID: 27530761.

  12. Okada H, Takabatake R, Honda M, Takegoshi K, Yamashita T, Nakamura M, Shirasaki T, Sakai Y, Shimakami T, Nagata N, Takamura T, Tanaka T, Kaneko S. Peretinoin, an acyclic retinoid, suppresses steatohepatitis and tumorigenesis by activating autophagy in mice fed an atherogenic high-fat diet. Oncotarget. 2017 Jun 20;8(25):39978-39993. doi: 10.18632/oncotarget.18116. PubMed PMID: 28591717; PubMed Central PMCID: PMC5522259.

​2016

  1. Ando H, Ushijima K, Shimba S, Fujimura A. Daily Fasting Blood Glucose Rhythm in Male Mice: A Role of the Circadian Clock in the Liver. Endocrinology. 2016 Feb;157(2):463-9. doi: 10.1210/en.2015-1376. PubMed PMID: 26653333.

  2. Ando H, Nakano K, Ushijima K, Kurokawa S, Washino S, Hosohata K, Morita T, Fujimura A. Influence of genetic polymorphisms of multidrug and toxin extrusion protein 1 on its mRNA expression in peripheral blood cells. J Pharmacol Sci. 2016 Jun;131(2):138-40. doi: 10.1016/j.jphs.2016.03.002. PubMed PMID: 27025966.

  3. Hosohata K, Washino S, Kubo T, Natsui S, Fujisaki A, Kurokawa S, Ando H, Fujimura A, Morita T. Early prediction of cisplatin-induced nephrotoxicity by urinary vanin-1 in patients with urothelial carcinoma. Toxicology. 2016 Jun 1;359-360:71-5. doi: 10.1016/j.tox.2016.06.011. PubMed PMID: 27317936.

  4. Hosohata K, Yoshioka D, Tanaka A, Ando H, Fujimura A. Early urinary biomarkers for renal tubular damage in spontaneously hypertensive rats on a high salt intake. Hypertens Res. 2016 Jan;39(1):19-26. doi: 10.1038/hr.2015.103. PubMed PMID: 26376947.

  5. Chen G, Ni Y, Nagata N, Xu L, Ota T. Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease. Int J Mol Sci. 2016 Aug 23;17(9). pii: E1379. doi: 10.3390/ijms17091379. Review. PubMed PMID: 27563875; PubMed Central PMCID: PMC5037659.

  6. Zhuge F, Ni Y, Nagashimada M, Nagata N, Xu L, Mukaida N, Kaneko S, Ota T. DPP-4 Inhibition by Linagliptin Attenuates Obesity-Related Inflammation and Insulin Resistance by Regulating M1/M2 Macrophage Polarization. Diabetes. 2016 Oct;65(10):2966-79. doi: 10.2337/db16-0317. PubMed PMID: 27445264.

  7. Kimura K, Tanida M, Nagata N, Inaba Y, Watanabe H, Nagashimada M, Ota T, Asahara S, Kido Y, Matsumoto M, Toshinai K, Nakazato M, Shibamoto T, Kaneko S, Kasuga M, Inoue H. Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor. Cell Rep. 2016 Mar 15;14(10):2362-74. doi: 10.1016/j.celrep.2016.02.032. PubMed PMID: 26947072.

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